Paget's disease is a chronic disorder of the adult skeleton characterized by focal dys-regulation of bone remodelling. The aim of this study was to demonstrate the contribution of bone scintigraphy to the diagnosis of Paget's disease. The study was observational, cross-sectional and descriptive. It included patients who underwent bone scintigraphy in the nuclear medicine department of Dakar's Idrissa Pouye General Hospital from January 2020 to June 2023, and whose results suspected or confirmed Paget's disease of the bone. We collected a total of seven (07) patients during the study period, six (06) of whom were male with an average age of 67.42 years. Two (02) reasons justified the performance of scintigraphy in these patients. These were suspicion of Paget's disease and assessment of bone extension of prostate cancer with incidental discovery of Paget's disease. Two patients (28.57% of cases) had the monostotic form and five (71.43% of cases) had the polyostotic form. All lesions found on bone scans were hyper-fixating. Three (03) patients showed bone deformities, notably deformities of the long bones, and two (02) had typical osteocondensing (hyperfixation) images of the vertebrae, giving them a "Mickey Mouse" or clover appearance. Whole-body bone scintigraphy has made an important contribution to the diagnosis and assessment of the extent of Paget's disease, with a favourable dosimetric ratio.
| Published in | European Journal of Biophysics (Volume 12, Issue 1) |
| DOI | 10.11648/ejb.20241201.11 |
| Page(s) | 1-5 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Paget's Disease, Bone Scintigraphy, Dakar
| [1] | Audran M, Baslé MF. Maladie osseuse de Paget. EMC (Elsevier Masson SAS, Paris), Traité de Médecine Akos 2007; 7: 0650. Doi: 10.1016/S1634-6939(07)39649-X |
| [2] | Renier JC, Fanello S, Rodriguez N, Audran M. Current prevalence of Paget’s disease of bone in a region of France (Anjou). Rev Rhum 1995; 62: 571-5. Corpus ID: 36902759. |
| [3] | Kanis JA. Pathophysiology and treatment of paget’s disease of bone. London: Martin Dunitz; 1991. https://doi.org/10.1302/0301-620X.81B3.0810562 |
| [4] | Van Staa TP, Selby P, Leufkens HG, Lyles K, Sprafka JM, Cooper C. Incidence and natural history of Paget’s disease of bone in England and Wales. J Bone Miner Res 2002; 17: 465-71. https://doi.org/10.1359/jbmr.2002.17.3.465 |
| [5] | Stuart HR, Corral-Gudino L, Cooper C, Francis RM, Fraser WD, Gennari L and al. Diagnosis and Management of Paget’s Disease of Bone in Adults: A Clinical Guideline. Journal of Bone and Mineral Research 2018; 1-26. https://doi.org/10.1002/jbmr.3657 |
| [6] | Bertoldi I, Cantarini L, Filippou G, Frediani B. Paget’s disease. Reumatismo, 2014; 66 (2): 171-83. DOI: 10.4081/reumatismo.2014.789 |
| [7] | Sheane BJ, Delaney H, Doran MF, Cunnane G. A Classical Presentation of Paget Disease of Bone. JCR: Journal of Clinical Rheumatology 2008; 14(6): 373. doi: 10.1097/RHU.0b013e31818f9a44 |
| [8] | Iwamoto SJ, Rothman MS, Duan S, Baker JC, Whyte MP. Early-onset Paget's disease of bone in a Mexican family caused by a novel tandem duplication (77dup27) in TNFRSF11A that encodes RANK. Bone 2020; 133: 1-7. doi: 10.1016/j.bone.2020.115224. |
| [9] | Trabelsi K, Bez IE, Letaief B, Dhaouadi B, Mhiri A, Slim I, Slimene MFB. Découverte fortuite de maladie de Paget sur une scintigraphie osseuse. Médecine nucléaire 2017; 41(3): 196-7. https://doi.org/10.1016/j.mednuc.2017.02.159 |
| [10] | Delmas PD. Biochemical markers of bone turnover in Paget’s disease of bone. J Bone Miner Res 1999; 14(l2): 66-9. doi: 10.1002/jbmr.5650140213. |
| [11] | Garnero P, Gineyts E, Schaffer AV, Seaman J, Delmas PD. Measurement of urinary excretion of nonisomerized and betaisomerized forms of type I collagen breakdown products to monitor the effects of the bisphosphonate zoledronate in Paget’s disease. Arthritis Rheum 1998; 41: 354-60. doi: 10.1002/1529-0131(199802)41:2<354::AID-ART20>3.0.CO;2-5. |
| [12] | Garnero P, Fledelius C, Gineyts E, Serre CM, Vignot E, Delmas PD. Decreased beta-isomerization of the C-terminal telopeptide of type I collagen alpha 1 chain in Paget’s disease of bone. J Bone Miner Res 1997; 12: 1407-15. doi: 10.1359/jbmr.1997.12.9.1407. |
| [13] | Meunier PJ. La maladie osseuse de Paget. De l’histopathologie au diagnostic. Montrouge: John Libbey; 1998. ISBN 2-7420-0142-5 |
| [14] | Corral-Gudino L, Borao-Cengotita-Bengoa M, Del Pino-Montes J, Ralston SH. Epidemiology of Paget’s disease of bone: a systematic review and meta-analysis of secular changes. Bone. 2013; 55(2): 347–52. doi: 10.1016/j.bone.2013.04.024. |
| [15] | Benider H, Taleb S, Guensi A. Apport de la scintigraphie osseuse dans la suspicion de la maladie de Paget: à propos d’un cas. Médecine nucléaire 2022; 46(2): 90. https://doi.org/10.1016/j.mednuc.2022.01.102 |
APA Style
Bathily, E. H. A. L., Fachinan, O. H., Diop, O., Djigo, M. S., Thiaw, G., et al. (2024). 99mTc-HMDP Bone Scintigraphy and Paget's Disease: About 7 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital in Dakar. European Journal of Biophysics, 12(1), 1-5. https://doi.org/10.11648/ejb.20241201.11
ACS Style
Bathily, E. H. A. L.; Fachinan, O. H.; Diop, O.; Djigo, M. S.; Thiaw, G., et al. 99mTc-HMDP Bone Scintigraphy and Paget's Disease: About 7 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital in Dakar. Eur. J. Biophys. 2024, 12(1), 1-5. doi: 10.11648/ejb.20241201.11
AMA Style
Bathily EHAL, Fachinan OH, Diop O, Djigo MS, Thiaw G, et al. 99mTc-HMDP Bone Scintigraphy and Paget's Disease: About 7 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital in Dakar. Eur J Biophys. 2024;12(1):1-5. doi: 10.11648/ejb.20241201.11
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Download@article{10.11648/ejb.20241201.11,
author = {El Hadji Amadou Lamine Bathily and Olatounde Herbert Fachinan and Ousseynou Diop and Mamoudou Salif Djigo and Gora Thiaw and Kalidou Gueye and Mohamed Chekhma and Boucar Ndong and Omar Ndoye and Mamadou Mbodj},
title = {99mTc-HMDP Bone Scintigraphy and Paget's Disease: About 7 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital in Dakar},
journal = {European Journal of Biophysics},
volume = {12},
number = {1},
pages = {1-5},
doi = {10.11648/ejb.20241201.11},
url = {https://doi.org/10.11648/ejb.20241201.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.ejb.20241201.11},
abstract = {Paget's disease is a chronic disorder of the adult skeleton characterized by focal dys-regulation of bone remodelling. The aim of this study was to demonstrate the contribution of bone scintigraphy to the diagnosis of Paget's disease. The study was observational, cross-sectional and descriptive. It included patients who underwent bone scintigraphy in the nuclear medicine department of Dakar's Idrissa Pouye General Hospital from January 2020 to June 2023, and whose results suspected or confirmed Paget's disease of the bone. We collected a total of seven (07) patients during the study period, six (06) of whom were male with an average age of 67.42 years. Two (02) reasons justified the performance of scintigraphy in these patients. These were suspicion of Paget's disease and assessment of bone extension of prostate cancer with incidental discovery of Paget's disease. Two patients (28.57% of cases) had the monostotic form and five (71.43% of cases) had the polyostotic form. All lesions found on bone scans were hyper-fixating. Three (03) patients showed bone deformities, notably deformities of the long bones, and two (02) had typical osteocondensing (hyperfixation) images of the vertebrae, giving them a "Mickey Mouse" or clover appearance. Whole-body bone scintigraphy has made an important contribution to the diagnosis and assessment of the extent of Paget's disease, with a favourable dosimetric ratio.
},
year = {2024}
}
TY - JOUR T1 - 99mTc-HMDP Bone Scintigraphy and Paget's Disease: About 7 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital in Dakar AU - El Hadji Amadou Lamine Bathily AU - Olatounde Herbert Fachinan AU - Ousseynou Diop AU - Mamoudou Salif Djigo AU - Gora Thiaw AU - Kalidou Gueye AU - Mohamed Chekhma AU - Boucar Ndong AU - Omar Ndoye AU - Mamadou Mbodj Y1 - 2024/02/05 PY - 2024 N1 - https://doi.org/10.11648/ejb.20241201.11 DO - 10.11648/ejb.20241201.11 T2 - European Journal of Biophysics JF - European Journal of Biophysics JO - European Journal of Biophysics SP - 1 EP - 5 PB - Science Publishing Group SN - 2329-1737 UR - https://doi.org/10.11648/ejb.20241201.11 AB - Paget's disease is a chronic disorder of the adult skeleton characterized by focal dys-regulation of bone remodelling. The aim of this study was to demonstrate the contribution of bone scintigraphy to the diagnosis of Paget's disease. The study was observational, cross-sectional and descriptive. It included patients who underwent bone scintigraphy in the nuclear medicine department of Dakar's Idrissa Pouye General Hospital from January 2020 to June 2023, and whose results suspected or confirmed Paget's disease of the bone. We collected a total of seven (07) patients during the study period, six (06) of whom were male with an average age of 67.42 years. Two (02) reasons justified the performance of scintigraphy in these patients. These were suspicion of Paget's disease and assessment of bone extension of prostate cancer with incidental discovery of Paget's disease. Two patients (28.57% of cases) had the monostotic form and five (71.43% of cases) had the polyostotic form. All lesions found on bone scans were hyper-fixating. Three (03) patients showed bone deformities, notably deformities of the long bones, and two (02) had typical osteocondensing (hyperfixation) images of the vertebrae, giving them a "Mickey Mouse" or clover appearance. Whole-body bone scintigraphy has made an important contribution to the diagnosis and assessment of the extent of Paget's disease, with a favourable dosimetric ratio. VL - 12 IS - 1 ER -
Nuclear Medicine Department, Idrissa Pouye General Hospital (HOGIP), Dakar, Senegal; Biophysical Laboratory, Faculty of Medicine, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University (UCAD), Dakar, Senegal
