Oxidants-Antioxidants, The Biological Balance
View Published Articles →01About This Special Issue
Imbalance between the production of reactive oxygen species (ROS) and the detoxification of their reactive intermediates by antioxidants causes oxidative stress. Cells must respond to this imbalance before the highly reactive molecules damage cellular structures, particularly DNA. Severe and prolonged oxidative stress can trigger apoptosis and necrosis. Numerous pathological conditions have an oxidative stress component, including cataract, leukemia, melanoma, renal failure, diabetes, cardiovascular diseases and neurodegenerative diseases such as Alzheimer. Signaling pathways downstream of ROS detection phosphorylate the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) which binds the antioxidant response element within the promoters of genes encoding antioxidant enzymes and detoxifying enzymes. Key Nrf2 target genes include antioxidants such as glutathione peroxidases (GPx) and genes involved in superoxide metabolism. These genes, in addition to some other antioxidants, reduce oxidative stress by breaking down ROS. Analysis of oxidants-antioxidants balance may yield new insights or new approach to how dealing with many diseases and cancer.This special issue could serve as a background for the diseases which are due to oxidative stress and the role of antioxidants in scavenging the reactive oxygen species.
02Meet the Guest Editors
Our distinguished editors bring deep subject-matter expertise to curate high-quality research and ensure a rigorous peer-review process.
Lead Guest Editor
Mahmoud Ibrahim
Physics Department, Faculty of Science, Suez University, Suez, Egypt
Guest Editor
Lei Wang
Johns Hopkins University, School of Medicine, Wilmer Eye Institute, Baltimore, United States
Guest Editor
Bahram Alamdary Badlou
Research and Development Department, BBAdvies and Research Company (before University Medical Center Utrecht), Zeist, Netherlands
Guest Editor
Sudhir Rai
Department of Oral & Maxillofacial Surgery, Index institute of dental sciences, Bethesda, United States
Guest Editor
Gláucio Diré Feliciano
Analysis Laboratory Chemical and Biological (LAQB), Sector Center for Biological and Health Sciences, Foundation State University Center of the West Zone (UEZO), University of Pharmacy Unit (UFAR), Rio de Janeiro, Brazil
Guest Editor
Jing Zhang
Frontier Institute of Science and Techonogy, Xi'an Jiaotong University, China
Guest Editor
Yanbo Hu
College of Life Science, Northeast Forestry University, Harbin, China
Guest Editor
Noel Unciano
Environment and Biotechnology Division, Industrial Technology Development Institute, Taguig, Philippines
Guest Editor
Issa Ibraheem
Biomedical Engineering, Damascus University, Faculty of Biomedical Engineering, Damascus, Syria
Guest Editor
Ahmad Ali
Department of Life Sciences, University of Mumbai, Mumbai, India
Guest Editor
Seifollah Bahramikia
Department of Biology, Lorestan University, Khoramabad, Iran
03Published Articles
The following articles have been published in this special issue.
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Issue: Volume 3, Issue 2-2, April 2015Pages: 1-7Received: 16 January 2015Accepted: 19 January 2015Published: 2 March 2015Abstract: Metallothioneins (MTs) are cysteine-rich proteins, which have been implicated in regulation of physiological processes, such as cell growth, repair, differentiation, apoptosis and immunoregulation, as well as in the protection against heavy metals, oxidant damages, inflammation and other stressful conditions. To investigate their roles in physiolog... Show More
