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Determination and Investigation the Nitrofurazone’s Metabolite Semicarbazide in Macrobrachium Nipponese Prawns

Received: 26 May 2015     Accepted: 15 June 2015     Published: 2 July 2015
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Abstract

Semicarbazide (SEM) is the metabolite of the illegal veterinary nitrofurazone (NFZ) in aquatic animal. However there are increasing occurrences that SEM has been found in Macrobrachium Nipponese (M. Nipponese) prawns during the routine quality controls testing for aquatic food in China since 2008. To ascertain the presence and source of SEM, prawn samples were collected from different resources (i.e., aquatic product markets, natural waters, aquaculture farms) for qualitation and quantitation, and we incubated M. Nipponese larvae in the laboratory under control for observing the SEM. SEM was detected out in all the samples analyzed, including the wild-caught samples, and it presents a regular content relationship among three parts of prawns (i.e., the shell > head > muscle). This relationship was unrelated to sample resources. In addition, a natural increase of SEM was observed after the larvae metamorphosing into postlarvae. These findings in M. Nipponense prawns can provid new evidences for further confirmation and research of the natural occurrence of SEM.

Published in Science Discovery (Volume 3, Issue 2)
DOI 10.11648/j.sd.20150302.11
Page(s) 10-16
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Semicarbazide, Nitrofurazone, Macrobrachium Nipponese Prawn, Natural Occurrence, Shell

References
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[2] Nouws, J. F. M., Laurensen, J. Postmortal. Degradation of furazolidone andfuraltadone in edible tissues of calves. Veterinary Quarterly, 1990, 12, 56–59.
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[8] McCrackena, R., Hannab, B., Ennisa, D. The occurrence of semicarbazide in the muscle and shell of Bangladeshi fresh-water shrimp. Food Chem. 2011, 25, 1-6.
[9] Poucke,C. Van, DE Tavernier, C. Investigation into the Possible Natural Occurrence of Semicarbazide in Macrobrachium rosenbergii Prawns. J. Agric. Food Chem. 2011, 59, 2107–2112.
[10] Leitner, A., Zollner, P., Lindner, W. Determination of the metabolites of nitrofuran antibiotics in animal tissue by high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. 2001, 939, 49–58.
[11] Cooper, K. M., Mulder, P.P., Rhijn, J. A. van. Depletion of four nitrofuran antibiotics and their tissue-bound metabolites in porcine tissues and determination using LC-MS/MS and HPLC-UV. Food Addit Contam. 2005, 22(5), 406-414.
[12] Hu, Q. Z., Noll, R. J., Li, H. Y.; Makarov, A. The Orbitrap: a new mass spectrometer. J. Mass Spectrom. 2005, 40, 430–443.
[13] Nielen, M. W. F., Engelen, M.C. van; Zuiderent, R., Ramaker. R. Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and orbitrap mass spectrometry techniques. Analytica Chimica Acta. 2007, 586(14)122–129.
[14] Heeft, E. van, Bolck, Y. J. C., Beumer, B. Full-Scan Accurate Mass Selectivity of Ultra-Performance Liquid Chromatography Combined with Time-of-Flight and Orbitrap Mass Spectrometry in Hormone and Veterinary Drug Residue Analysis. Journal of the American Society for Mass Spectrometry. 2009, 20(3), 451–463.
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[18] Yu H. J.;Li B.; Cai Y. Q. Determination of Semicarbazide content in crustaceans by Liquid chromatography tandem mass spectrometry. Chinese Journal of Analytical Chemistry. 2012, 4(10), 1530-1535.
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  • APA Style

    Bing Li, Hui-juan Yu, Yun-liang Yang. (2015). Determination and Investigation the Nitrofurazone’s Metabolite Semicarbazide in Macrobrachium Nipponese Prawns. Science Discovery, 3(2), 10-16. https://doi.org/10.11648/j.sd.20150302.11

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    ACS Style

    Bing Li; Hui-juan Yu; Yun-liang Yang. Determination and Investigation the Nitrofurazone’s Metabolite Semicarbazide in Macrobrachium Nipponese Prawns. Sci. Discov. 2015, 3(2), 10-16. doi: 10.11648/j.sd.20150302.11

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    AMA Style

    Bing Li, Hui-juan Yu, Yun-liang Yang. Determination and Investigation the Nitrofurazone’s Metabolite Semicarbazide in Macrobrachium Nipponese Prawns. Sci Discov. 2015;3(2):10-16. doi: 10.11648/j.sd.20150302.11

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  • @article{10.11648/j.sd.20150302.11,
      author = {Bing Li and Hui-juan Yu and Yun-liang Yang},
      title = {Determination and Investigation the Nitrofurazone’s Metabolite Semicarbazide in Macrobrachium Nipponese Prawns},
      journal = {Science Discovery},
      volume = {3},
      number = {2},
      pages = {10-16},
      doi = {10.11648/j.sd.20150302.11},
      url = {https://doi.org/10.11648/j.sd.20150302.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20150302.11},
      abstract = {Semicarbazide (SEM) is the metabolite of the illegal veterinary nitrofurazone (NFZ) in aquatic animal. However there are increasing occurrences that SEM has been found in Macrobrachium Nipponese (M. Nipponese) prawns during the routine quality controls testing for aquatic food in China since 2008. To ascertain the presence and source of SEM, prawn samples were collected from different resources (i.e., aquatic product markets, natural waters, aquaculture farms) for qualitation and quantitation, and we incubated M. Nipponese larvae in the laboratory under control for observing the SEM. SEM was detected out in all the samples analyzed, including the wild-caught samples, and it presents a regular content relationship among three parts of prawns (i.e., the shell > head > muscle). This relationship was unrelated to sample resources. In addition, a natural increase of SEM was observed after the larvae metamorphosing into postlarvae. These findings in M. Nipponense prawns can provid new evidences for further confirmation and research of the natural occurrence of SEM.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Determination and Investigation the Nitrofurazone’s Metabolite Semicarbazide in Macrobrachium Nipponese Prawns
    AU  - Bing Li
    AU  - Hui-juan Yu
    AU  - Yun-liang Yang
    Y1  - 2015/07/02
    PY  - 2015
    N1  - https://doi.org/10.11648/j.sd.20150302.11
    DO  - 10.11648/j.sd.20150302.11
    T2  - Science Discovery
    JF  - Science Discovery
    JO  - Science Discovery
    SP  - 10
    EP  - 16
    PB  - Science Publishing Group
    SN  - 2331-0650
    UR  - https://doi.org/10.11648/j.sd.20150302.11
    AB  - Semicarbazide (SEM) is the metabolite of the illegal veterinary nitrofurazone (NFZ) in aquatic animal. However there are increasing occurrences that SEM has been found in Macrobrachium Nipponese (M. Nipponese) prawns during the routine quality controls testing for aquatic food in China since 2008. To ascertain the presence and source of SEM, prawn samples were collected from different resources (i.e., aquatic product markets, natural waters, aquaculture farms) for qualitation and quantitation, and we incubated M. Nipponese larvae in the laboratory under control for observing the SEM. SEM was detected out in all the samples analyzed, including the wild-caught samples, and it presents a regular content relationship among three parts of prawns (i.e., the shell > head > muscle). This relationship was unrelated to sample resources. In addition, a natural increase of SEM was observed after the larvae metamorphosing into postlarvae. These findings in M. Nipponense prawns can provid new evidences for further confirmation and research of the natural occurrence of SEM.
    VL  - 3
    IS  - 2
    ER  - 

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Author Information
  • Suzhou Industrial Park, Environmental Monitoring Center, Suzhou, Jiangsu, China

  • East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences (CAFS), Shanghai, China

  • Huawei Technologies Co., Ltd. Suzhou, Jiangsu, China

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