Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions

Galiya Ibadullayeva; Volodimir Grudko; Аssyl Boshkayeva; Zuriyadda Sakipova; Talgat Dzalgasbayev; Gulbaram Ustenova; Kaldanay Kozhanova; Nazerke Uristemkhankyzy; Eduard Bissenbaev; Nurgan Tussupova; Sholpan Mulkibayeva; Ilyas Tazabekov

doi:doi:10.11648/j.cmr.20160503.15

Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions

Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, Gulbaram Ustenova, Kaldanay Kozhanova, Nazerke Uristemkhankyzy, Eduard Bissenbaev, Nurgan Tussupova, Sholpan Mulkibayeva, Ilyas Tazabekov

Published in Clinical Medicine Research (Volume 5, Issue 3)

Received: 20 February 2016 Accepted: 25 April 2016 Published: 13 May 2016

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Abstract

We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO₂), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.

Published in	Clinical Medicine Research (Volume 5, Issue 3)
DOI	10.11648/j.cmr.20160503.15
Page(s)	39-44
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Tablets, CO₂-Extracts, Quality Indicators, Camphor, Carotenoids, Acorus Calamus, Calendula Officinalis

References

[1]	State Pharmacopoeia of the Republic of Kazakhstan (SF) RK І, t. 1, 2.2.25.
[2]	State Pharmacopoeia of the Republic of Kazakhstan (SF) RK І, t., 2.2.27.
[3]	State Pharmacopoeia of the Republic of Kazakhstan (SF) RK І, t., 2.2.28.
[4]	Kasyanov G. I., Mkhitaryants G. A. Sub - and supercritical CO₂-extraction of valuable components from vegetable raw materials // Collection of materials of the international scientific and technical Internet conference "The Sub — and Supercritical Fluid Technologies in the Food Industry". – Krasnodar: KubGTU, 2012. – P. 80-83.
[5]	Ustenova G. O. Extraction by the liquefied gases. – Manual, Almaty: КаzNMU, 2010. – 66 p.
[6]	Kasyanov G. I. CO₂-extracts. Production and application. – Monograph: Under the editorship of the prof. Scherbakov V. G. – Krasnodar: Ecoinvestment, 2010. – 176 p.
[7]	Ibadullayeva G. S., Pichkhadze G. M., Ustenova G. O., Dilbarkhanov R., Tikhonova S. A., Grudko V. A., Bevz N. Y., Yudina Yu. V. The Chemical composition of CO₂–extract of the Acorus marsh, received in subcritical conditions // The Chemical and pharmaceutical magazine. – M, 2015. - No. 5. – P. 56-60.
[8]	Ibadullayeva G. S., Bochkhaeva A. K., Ustenova G. O., Datkhayev U. M., Sakipova Z. B., Tikhonova S. A., Grudko V. A., Bevz N. Y. Standardization of Calamus CO₂-extract and study of individual fractions of herbal preparations // Life Science Journal. – 2014. - №11 (5s) // http://www // Life Science Journal. – 2014. - №11(2s). - P. 25-27.
[9]	Shikov A. N., Makarov G. V., Ryzhenkov V. E. Vegetable oils and oil extracts: technology, standardization, properties. - M.: Publishing House. Home "Russian doctor". - 2004.
[10]	Tinctures, extracts, elixirs and standardization / edited by Bagirova V. L. and A. V. Severtsev – St. P: Specialized Literature, 2001.
[11]	Stasyeva Oksana Nikolaevna. Improvement of technology of production and application of CO₂-extracts from vegetable raw materials: the dissertation... of candidate of technical sciences: 05.18.10. - Krasnodar, 2005. - 153 p.
[12]	Savin, Vladimir Nikolayevich. The improving technology for obtaining valuable components from vegetative raw materials with environmentally safe physical methods: dissertation... of candidate of technical sciences: 05.18.01 Krasnodar, 2006. - 163 p.
[13]	Kasyanov G. I., Malashenko N. L., Silinskaya S. M. Technics and Technology of using carbon dioxide as the extracting medium // News of University. Food technology. 2014. – N. 4. - P. 6-9.
[14]	Kasyanov G. I. Technics and Technology of using carbon dioxide in sub- and supercritical state // Bulletin of the Voronezh state University of engineering technologies. 2014. - No. 1. - P. 130-135.
[15]	Gavashelishvili, L. V. Development of composition and technology of lingual tablets containing chlorophyllipt thick extract and thyme liquid extract: the dissertation... of candidate of pharmaceutical sciences: 14.04.01 / Gavashelishvili Lali Vasilyevna; [a defence place: "Pyatigorsk state pharmaceutical academy"]. - Pyatigorsk, 2011. - 122 p.
[16]	Development of the technology of granules of Linden extract, pills of extract hibiscus and rosehip extract: abstract of thesis... candidate of pharmaceutical sciences: 15.00.01 / Paleskin Anatoly Vladimirovich; [a defence place: St. - Petersburg state chem.-pharmacist. acad.] - St. Petersburg, 2009. - 29 P.
[17]	The draft of Provisional Analytic Normative Document (PAND) Extract of the Calamus.
[18]	The draft of Provisional Analytic Normative Document (PAND) Extract of the Calendula.

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APA Style

Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, et al. (2016). Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clinical Medicine Research, 5(3), 39-44. https://doi.org/10.11648/j.cmr.20160503.15

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ACS Style

Galiya Ibadullayeva; Volodimir Grudko; Аssyl Boshkayeva; Zuriyadda Sakipova; Talgat Dzalgasbayev, et al. Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clin. Med. Res. 2016, 5(3), 39-44. doi: 10.11648/j.cmr.20160503.15

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AMA Style

Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, et al. Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clin Med Res. 2016;5(3):39-44. doi: 10.11648/j.cmr.20160503.15

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@article{10.11648/j.cmr.20160503.15,
  author = {Galiya Ibadullayeva and Volodimir Grudko and Аssyl Boshkayeva and Zuriyadda Sakipova and Talgat Dzalgasbayev and Gulbaram Ustenova and Kaldanay Kozhanova and Nazerke Uristemkhankyzy and Eduard Bissenbaev and Nurgan Tussupova and Sholpan Mulkibayeva and Ilyas Tazabekov},
  title = {Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions},
  journal = {Clinical Medicine Research},
  volume = {5},
  number = {3},
  pages = {39-44},
  doi = {10.11648/j.cmr.20160503.15},
  url = {https://doi.org/10.11648/j.cmr.20160503.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20160503.15},
  abstract = {We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.},
 year = {2016}
}

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TY  - JOUR
T1  - Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions
AU  - Galiya Ibadullayeva
AU  - Volodimir Grudko
AU  - Аssyl Boshkayeva
AU  - Zuriyadda Sakipova
AU  - Talgat Dzalgasbayev
AU  - Gulbaram Ustenova
AU  - Kaldanay Kozhanova
AU  - Nazerke Uristemkhankyzy
AU  - Eduard Bissenbaev
AU  - Nurgan Tussupova
AU  - Sholpan Mulkibayeva
AU  - Ilyas Tazabekov
Y1  - 2016/05/13
PY  - 2016
N1  - https://doi.org/10.11648/j.cmr.20160503.15
DO  - 10.11648/j.cmr.20160503.15
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 39
EP  - 44
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20160503.15
AB  - We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.
VL  - 5
IS  - 3
ER  -

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Author Information

Galiya Ibadullayeva

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Volodimir Grudko

Pharmaceutical Faculty, National Pharmaceutical University, Kharkov, Ukraine
Аssyl Boshkayeva

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Zuriyadda Sakipova

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Talgat Dzalgasbayev

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Gulbaram Ustenova

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Kaldanay Kozhanova

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Nazerke Uristemkhankyzy

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Eduard Bissenbaev

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Nurgan Tussupova

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Sholpan Mulkibayeva

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Ilyas Tazabekov

Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

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Plain Text BibTeX RIS

APA Style

Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, et al. (2016). Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clinical Medicine Research, 5(3), 39-44. https://doi.org/10.11648/j.cmr.20160503.15

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ACS Style

Galiya Ibadullayeva; Volodimir Grudko; Аssyl Boshkayeva; Zuriyadda Sakipova; Talgat Dzalgasbayev, et al. Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clin. Med. Res. 2016, 5(3), 39-44. doi: 10.11648/j.cmr.20160503.15

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AMA Style

Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, et al. Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clin Med Res. 2016;5(3):39-44. doi: 10.11648/j.cmr.20160503.15

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@article{10.11648/j.cmr.20160503.15,
  author = {Galiya Ibadullayeva and Volodimir Grudko and Аssyl Boshkayeva and Zuriyadda Sakipova and Talgat Dzalgasbayev and Gulbaram Ustenova and Kaldanay Kozhanova and Nazerke Uristemkhankyzy and Eduard Bissenbaev and Nurgan Tussupova and Sholpan Mulkibayeva and Ilyas Tazabekov},
  title = {Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions},
  journal = {Clinical Medicine Research},
  volume = {5},
  number = {3},
  pages = {39-44},
  doi = {10.11648/j.cmr.20160503.15},
  url = {https://doi.org/10.11648/j.cmr.20160503.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20160503.15},
  abstract = {We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.},
 year = {2016}
}

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TY  - JOUR
T1  - Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions
AU  - Galiya Ibadullayeva
AU  - Volodimir Grudko
AU  - Аssyl Boshkayeva
AU  - Zuriyadda Sakipova
AU  - Talgat Dzalgasbayev
AU  - Gulbaram Ustenova
AU  - Kaldanay Kozhanova
AU  - Nazerke Uristemkhankyzy
AU  - Eduard Bissenbaev
AU  - Nurgan Tussupova
AU  - Sholpan Mulkibayeva
AU  - Ilyas Tazabekov
Y1  - 2016/05/13
PY  - 2016
N1  - https://doi.org/10.11648/j.cmr.20160503.15
DO  - 10.11648/j.cmr.20160503.15
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 39
EP  - 44
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20160503.15
AB  - We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.
VL  - 5
IS  - 3
ER  -

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