Two most important physiological functions of intestinal epithelial cells (IECs) are intestinal secretion and barrier function in order to protect the host from invasive microorganisms. Acetylcholine (ACh) is regarded as a central molecule for the regulation of these gut functions. Although, ACh is considered as a classical neurotransmitter, numerous studies report the synthesis and release of ACh from non-neuronal epithelial cells and are believed to regulate gut functions via cholinergic activation. Recently, it is established that IECs express M1 and M3 muscarinic acetylcholine receptors (mAChRs). Although, the role of M3 mAChR-mediated intestinal secretion in Ussing Chamber has been highly established, little is known about M1 mAChR-mediated intestinal secretion and barrier function. Here, we review the current knowledge about the functions of M1 and M3 mAChRs and their downstream signaling in the regulation of intestinal secretion and barrier function. We also discuss the role of mAChRs in IECs under inflammatory conditions.
| Published in | American Journal of Life Sciences (Volume 3, Issue 4) |
| DOI | 10.11648/j.ajls.20150304.19 |
| Page(s) | 311-315 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Intestinal Secretion, Barrier Function, mAChR, Inflammation
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APA Style
Md. Rafiqul Islam Khan, Takashi Yazawa, Junsuke Uwada, Abu Syed Md. Anisuzzaman, Takanobu Taniguchi. (2015). Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor. American Journal of Life Sciences, 3(4), 311-315. https://doi.org/10.11648/j.ajls.20150304.19
ACS Style
Md. Rafiqul Islam Khan; Takashi Yazawa; Junsuke Uwada; Abu Syed Md. Anisuzzaman; Takanobu Taniguchi. Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor. Am. J. Life Sci. 2015, 3(4), 311-315. doi: 10.11648/j.ajls.20150304.19
AMA Style
Md. Rafiqul Islam Khan, Takashi Yazawa, Junsuke Uwada, Abu Syed Md. Anisuzzaman, Takanobu Taniguchi. Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor. Am J Life Sci. 2015;3(4):311-315. doi: 10.11648/j.ajls.20150304.19
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Download@article{10.11648/j.ajls.20150304.19,
author = {Md. Rafiqul Islam Khan and Takashi Yazawa and Junsuke Uwada and Abu Syed Md. Anisuzzaman and Takanobu Taniguchi},
title = {Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor},
journal = {American Journal of Life Sciences},
volume = {3},
number = {4},
pages = {311-315},
doi = {10.11648/j.ajls.20150304.19},
url = {https://doi.org/10.11648/j.ajls.20150304.19},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150304.19},
abstract = {Two most important physiological functions of intestinal epithelial cells (IECs) are intestinal secretion and barrier function in order to protect the host from invasive microorganisms. Acetylcholine (ACh) is regarded as a central molecule for the regulation of these gut functions. Although, ACh is considered as a classical neurotransmitter, numerous studies report the synthesis and release of ACh from non-neuronal epithelial cells and are believed to regulate gut functions via cholinergic activation. Recently, it is established that IECs express M1 and M3 muscarinic acetylcholine receptors (mAChRs). Although, the role of M3 mAChR-mediated intestinal secretion in Ussing Chamber has been highly established, little is known about M1 mAChR-mediated intestinal secretion and barrier function. Here, we review the current knowledge about the functions of M1 and M3 mAChRs and their downstream signaling in the regulation of intestinal secretion and barrier function. We also discuss the role of mAChRs in IECs under inflammatory conditions.},
year = {2015}
}
TY - JOUR T1 - Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor AU - Md. Rafiqul Islam Khan AU - Takashi Yazawa AU - Junsuke Uwada AU - Abu Syed Md. Anisuzzaman AU - Takanobu Taniguchi Y1 - 2015/07/18 PY - 2015 N1 - https://doi.org/10.11648/j.ajls.20150304.19 DO - 10.11648/j.ajls.20150304.19 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 311 EP - 315 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20150304.19 AB - Two most important physiological functions of intestinal epithelial cells (IECs) are intestinal secretion and barrier function in order to protect the host from invasive microorganisms. Acetylcholine (ACh) is regarded as a central molecule for the regulation of these gut functions. Although, ACh is considered as a classical neurotransmitter, numerous studies report the synthesis and release of ACh from non-neuronal epithelial cells and are believed to regulate gut functions via cholinergic activation. Recently, it is established that IECs express M1 and M3 muscarinic acetylcholine receptors (mAChRs). Although, the role of M3 mAChR-mediated intestinal secretion in Ussing Chamber has been highly established, little is known about M1 mAChR-mediated intestinal secretion and barrier function. Here, we review the current knowledge about the functions of M1 and M3 mAChRs and their downstream signaling in the regulation of intestinal secretion and barrier function. We also discuss the role of mAChRs in IECs under inflammatory conditions. VL - 3 IS - 4 ER -
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