Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis

Blerina Dhamo; Arben Pilaca; Gentian Vyshka

doi:doi:10.11648/j.ajim.20170505.14

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Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis

Blerina Dhamo, Arben Pilaca, Gentian Vyshka

Published in American Journal of Internal Medicine (Volume 5, Issue 5)

Received: 31 January 2017 Accepted: 21 February 2017 Published: 23 October 2017

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Abstract

The hypereosinophilic syndromes represent a group of disorders marked by the sustained overproduction of eosinophils, with eosinophilic infiltration of tissues and mediator release, leading to multiple organic damages. Churg-Strauss syndrome is a rare disorder characterized by systemic small vessel vasculitis, extra vascular granulomas and hypereosinophilia, characteristically occurring in people with background late-onset asthma and allergic rhinitis. Its annual incidence is between 0 and 4 per million of population. The authors present the case of a 72 year old Caucasian female patient, admitted at the Hygeia Hospital Tirana due to a hypereosinophilic syndrome. The thorax CT scan verified bilateral pseudo nodular pulmonary infiltrates; the head MRI showed vascular bilateral lesions in periventricular white matter and centrum semiovale, right internal capsule and left caudate nucleus, and the nerve conduction study (NCS) revealed a distal mixed polyneuropathy. A fibro-gastroscopy with biopsy suggested an atrophic gastritis. The patient underwent a course of treatment with intravenous methylprednisolone, tapered thereafter to oral prednisone together with cyclophosphamide, with a prompt improvement of the clinical picture.

Published in	American Journal of Internal Medicine (Volume 5, Issue 5)
DOI	10.11648/j.ajim.20170505.14
Page(s)	83-85
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Hypereosinophilia, Churg-Strauss Syndrome, Vasculitis, Systemic Changes

References

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[2]	Galli SJ, Goetzl EJ. Eosinophils, basophils, and mast cells. In: Handin RI, Stossel TP, Lux SE, Stossel TP, eds. Blood: Principles and Practice of Hematology. Baltimore, Md: Lippincott Williams & Wilkins; 1995, pp. 621-640.
[3]	Klion AD, Bochner BS, Gleich GJ, Nutman TB, Rothenberg ME, Simon HU, et al. Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report. J Allergy Clin Immunol. 2006 Jun;117 (6): 1292-302.
[4]	Chusid MJ, Dale DC, West BC, Wolff SM. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore). 1975 Jan; 54 (1): 1-27.
[5]	Simon HU, Rothenberg ME, Bochner BS, Weller PF, Wardlaw AJ, Wechsler ME, et al. Refining the definition of hypereosinophilic syndrome. J Allergy Clin Immunol. 2010 Jul. 126 (1): 45-9.
[6]	Klion AD. Eosinophilic myeloproliferative disorders. Hematology Am Soc Hematol Educ Program. 2011; 2011: 257-63.
[7]	Liao W, Long H, Chang CC, Lu Q. The Eosinophil in Health and Disease: from Bench to Bedside and Back. Clin Rev Allergy Immunol. 2016 Apr; 50 (2): 125-39.
[8]	Valent P, Klion AD, Rosenwasser LJ, Arock M, Bochner BS, Butterfield JH, et al. ICON: Eosinophil Disorders. World Allergy Organ J. 2012 Dec; 5 (12): 174-81.
[9]	Sinico RA, Di Toma L, Maggiore U, Tosoni C, Bottero P, Sabadini E, et al. Renal involvement in Churg-Strauss syndrome. Am J Kidney Dis. 2006 May; 47 (5): 770-9.
[10]	Pagnoux C. Churg-Strauss syndrome: evolving concepts. Discov Med. 2010 Mar; 9 (46): 243-52.
[11]	Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum. 1990 Aug; 33 (8): 1094-100.
[12]	Mohammad AJ, Jacobsson LT, Westman KW, Sturfelt G, Segelmark M. Incidence and survival rates in Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa. Rheumatology (Oxford). 2009 Dec; 48 (12): 1560-5.
[13]	Sablé-Fourtassou R, Cohen P, Mahr A, Pagnoux C, Mouthon L, Jayne D, et al. Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome. Ann Intern Med. 2005 Nov 1; 143 (9): 632-8.
[14]	Gross WL, Reinhold-Keller E. Churg-Strauss Syndrome. Orphanet Encyclopedia. 2002, 1-7.
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APA Style

Blerina Dhamo, Arben Pilaca, Gentian Vyshka. (2017). Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis. American Journal of Internal Medicine, 5(5), 83-85. https://doi.org/10.11648/j.ajim.20170505.14

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ACS Style

Blerina Dhamo; Arben Pilaca; Gentian Vyshka. Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis. Am. J. Intern. Med. 2017, 5(5), 83-85. doi: 10.11648/j.ajim.20170505.14

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AMA Style

Blerina Dhamo, Arben Pilaca, Gentian Vyshka. Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis. Am J Intern Med. 2017;5(5):83-85. doi: 10.11648/j.ajim.20170505.14

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@article{10.11648/j.ajim.20170505.14,
  author = {Blerina Dhamo and Arben Pilaca and Gentian Vyshka},
  title = {Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis},
  journal = {American Journal of Internal Medicine},
  volume = {5},
  number = {5},
  pages = {83-85},
  doi = {10.11648/j.ajim.20170505.14},
  url = {https://doi.org/10.11648/j.ajim.20170505.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20170505.14},
  abstract = {The hypereosinophilic syndromes represent a group of disorders marked by the sustained overproduction of eosinophils, with eosinophilic infiltration of tissues and mediator release, leading to multiple organic damages. Churg-Strauss syndrome is a rare disorder characterized by systemic small vessel vasculitis, extra vascular granulomas and hypereosinophilia, characteristically occurring in people with background late-onset asthma and allergic rhinitis. Its annual incidence is between 0 and 4 per million of population. The authors present the case of a 72 year old Caucasian female patient, admitted at the Hygeia Hospital Tirana due to a hypereosinophilic syndrome. The thorax CT scan verified bilateral pseudo nodular pulmonary infiltrates; the head MRI showed vascular bilateral lesions in periventricular white matter and centrum semiovale, right internal capsule and left caudate nucleus, and the nerve conduction study (NCS) revealed a distal mixed polyneuropathy. A fibro-gastroscopy with biopsy suggested an atrophic gastritis. The patient underwent a course of treatment with intravenous methylprednisolone, tapered thereafter to oral prednisone together with cyclophosphamide, with a prompt improvement of the clinical picture.},
 year = {2017}
}

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TY  - JOUR
T1  - Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis
AU  - Blerina Dhamo
AU  - Arben Pilaca
AU  - Gentian Vyshka
Y1  - 2017/10/23
PY  - 2017
N1  - https://doi.org/10.11648/j.ajim.20170505.14
DO  - 10.11648/j.ajim.20170505.14
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 83
EP  - 85
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20170505.14
AB  - The hypereosinophilic syndromes represent a group of disorders marked by the sustained overproduction of eosinophils, with eosinophilic infiltration of tissues and mediator release, leading to multiple organic damages. Churg-Strauss syndrome is a rare disorder characterized by systemic small vessel vasculitis, extra vascular granulomas and hypereosinophilia, characteristically occurring in people with background late-onset asthma and allergic rhinitis. Its annual incidence is between 0 and 4 per million of population. The authors present the case of a 72 year old Caucasian female patient, admitted at the Hygeia Hospital Tirana due to a hypereosinophilic syndrome. The thorax CT scan verified bilateral pseudo nodular pulmonary infiltrates; the head MRI showed vascular bilateral lesions in periventricular white matter and centrum semiovale, right internal capsule and left caudate nucleus, and the nerve conduction study (NCS) revealed a distal mixed polyneuropathy. A fibro-gastroscopy with biopsy suggested an atrophic gastritis. The patient underwent a course of treatment with intravenous methylprednisolone, tapered thereafter to oral prednisone together with cyclophosphamide, with a prompt improvement of the clinical picture.
VL  - 5
IS  - 5
ER  -

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Author Information

Blerina Dhamo

Internal and Emergency Medicine Service, Hygeia Hospital, Tirana, Albania
Arben Pilaca

Internal and Emergency Medicine Service, Hygeia Hospital, Tirana, Albania
Gentian Vyshka

Faculty of Medicine, University of Medicine, Tirana, Albania

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Plain Text BibTeX RIS

APA Style

Blerina Dhamo, Arben Pilaca, Gentian Vyshka. (2017). Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis. American Journal of Internal Medicine, 5(5), 83-85. https://doi.org/10.11648/j.ajim.20170505.14

Copy | Download

ACS Style

Blerina Dhamo; Arben Pilaca; Gentian Vyshka. Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis. Am. J. Intern. Med. 2017, 5(5), 83-85. doi: 10.11648/j.ajim.20170505.14

Copy | Download

AMA Style

Blerina Dhamo, Arben Pilaca, Gentian Vyshka. Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis. Am J Intern Med. 2017;5(5):83-85. doi: 10.11648/j.ajim.20170505.14

Copy | Download

@article{10.11648/j.ajim.20170505.14,
  author = {Blerina Dhamo and Arben Pilaca and Gentian Vyshka},
  title = {Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis},
  journal = {American Journal of Internal Medicine},
  volume = {5},
  number = {5},
  pages = {83-85},
  doi = {10.11648/j.ajim.20170505.14},
  url = {https://doi.org/10.11648/j.ajim.20170505.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20170505.14},
  abstract = {The hypereosinophilic syndromes represent a group of disorders marked by the sustained overproduction of eosinophils, with eosinophilic infiltration of tissues and mediator release, leading to multiple organic damages. Churg-Strauss syndrome is a rare disorder characterized by systemic small vessel vasculitis, extra vascular granulomas and hypereosinophilia, characteristically occurring in people with background late-onset asthma and allergic rhinitis. Its annual incidence is between 0 and 4 per million of population. The authors present the case of a 72 year old Caucasian female patient, admitted at the Hygeia Hospital Tirana due to a hypereosinophilic syndrome. The thorax CT scan verified bilateral pseudo nodular pulmonary infiltrates; the head MRI showed vascular bilateral lesions in periventricular white matter and centrum semiovale, right internal capsule and left caudate nucleus, and the nerve conduction study (NCS) revealed a distal mixed polyneuropathy. A fibro-gastroscopy with biopsy suggested an atrophic gastritis. The patient underwent a course of treatment with intravenous methylprednisolone, tapered thereafter to oral prednisone together with cyclophosphamide, with a prompt improvement of the clinical picture.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Hypereosinophilic Syndrome - A Case with Churg Strauss Vasculitis
AU  - Blerina Dhamo
AU  - Arben Pilaca
AU  - Gentian Vyshka
Y1  - 2017/10/23
PY  - 2017
N1  - https://doi.org/10.11648/j.ajim.20170505.14
DO  - 10.11648/j.ajim.20170505.14
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 83
EP  - 85
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20170505.14
AB  - The hypereosinophilic syndromes represent a group of disorders marked by the sustained overproduction of eosinophils, with eosinophilic infiltration of tissues and mediator release, leading to multiple organic damages. Churg-Strauss syndrome is a rare disorder characterized by systemic small vessel vasculitis, extra vascular granulomas and hypereosinophilia, characteristically occurring in people with background late-onset asthma and allergic rhinitis. Its annual incidence is between 0 and 4 per million of population. The authors present the case of a 72 year old Caucasian female patient, admitted at the Hygeia Hospital Tirana due to a hypereosinophilic syndrome. The thorax CT scan verified bilateral pseudo nodular pulmonary infiltrates; the head MRI showed vascular bilateral lesions in periventricular white matter and centrum semiovale, right internal capsule and left caudate nucleus, and the nerve conduction study (NCS) revealed a distal mixed polyneuropathy. A fibro-gastroscopy with biopsy suggested an atrophic gastritis. The patient underwent a course of treatment with intravenous methylprednisolone, tapered thereafter to oral prednisone together with cyclophosphamide, with a prompt improvement of the clinical picture.
VL  - 5
IS  - 5
ER  -

Copy | Download