Aplastic Anemia in Egypt: Current Situation and Future Prospective

Safaa A. A. Khaled

doi:doi:10.11648/j.ajim.20160402.12

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Aplastic Anemia in Egypt: Current Situation and Future Prospective

Safaa A. A. Khaled

Published in American Journal of Internal Medicine (Volume 4, Issue 2)

Received: 6 April 2016 Accepted: 20 April 2016 Published: 11 May 2016

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Abstract

Aplastic anemia (AA) is a hypoproliferative anemia that led to a significant morbidity and mortality. Recently, dramatic improvement in prognosis of AA was achieved; this was in part due to advances in immunosuppressive therapy and HSCT. Nevertheless, AA is still one of the most challenging hematological disorders that could face a hematologist. This study was conducted at Assiut University Hospital (AUH), Assiut, Egypt to evaluate current situation and future prospective of AA. 63 patients with AA were prospectively enrolled in the study; they were admitted at the Hematology unit, AUH in the period 1stJan2011 to Feb2012, a 38 patients with iron deficiency anemia (IDA) were included for comparison. Patients' demographic and clinical data were collected through medical history and clinical examination. Both direct and indirect health care costs of anemia were assessed Direct parameters included doctors' and hospital fees, costs of laboratory investigations, medication fees and costs of HSCT or any procedure. Indirect costs included travelling expenses and earning losses. Social burden of anemia was estimated by anemia related morbidity and mortality. Data were analyzed with SPSSV.17, results showed that AA affected young age group with mean age 30.89±13.39 years, without sex predilection, acquired AA was more common than idiopathic (55.6% vs. 44.4%), however mortality was higher in idiopathic AA (46.2%). Causes of aplasia were exposure to chemicals, drugs and hepatitis in order. Only 63.5% of AA were admitted once and 47.6% in general ward, the mean hospital days for patients with AA was 17.73±11.10, compared to 8.32±6.69 in IDA, P=0.000, also higher socio-economic burden of AA was found compared with IDA. These results denoted that management of AA is still ineffective, and that there is a definite need for a strict plan to prevent incidence of AA, particularly in developing countries where effective management of AA is too expensive and relatively unavailable.

Published in	American Journal of Internal Medicine (Volume 4, Issue 2)
DOI	10.11648/j.ajim.20160402.12
Page(s)	36-42
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Aplastic Anemia, Future, Perspectives

References

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[18]	Kim JY, Shin S, HanK, et al. Relationship between socioeconomic status and anemia prevalence in adolescent girls based on the fourth and fifth Korea National Health and Nutrition Examination Surveys. Eur J Clin Nutr. 2014 Feb; 68 (2): 253-8.
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APA Style

Safaa A. A. Khaled. (2016). Aplastic Anemia in Egypt: Current Situation and Future Prospective. American Journal of Internal Medicine, 4(2), 36-42. https://doi.org/10.11648/j.ajim.20160402.12

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ACS Style

Safaa A. A. Khaled. Aplastic Anemia in Egypt: Current Situation and Future Prospective. Am. J. Intern. Med. 2016, 4(2), 36-42. doi: 10.11648/j.ajim.20160402.12

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Safaa A. A. Khaled. Aplastic Anemia in Egypt: Current Situation and Future Prospective. Am J Intern Med. 2016;4(2):36-42. doi: 10.11648/j.ajim.20160402.12

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@article{10.11648/j.ajim.20160402.12,
  author = {Safaa A. A. Khaled},
  title = {Aplastic Anemia in Egypt: Current Situation and Future Prospective},
  journal = {American Journal of Internal Medicine},
  volume = {4},
  number = {2},
  pages = {36-42},
  doi = {10.11648/j.ajim.20160402.12},
  url = {https://doi.org/10.11648/j.ajim.20160402.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20160402.12},
  abstract = {Aplastic anemia (AA) is a hypoproliferative anemia that led to a significant morbidity and mortality. Recently, dramatic improvement in prognosis of AA was achieved; this was in part due to advances in immunosuppressive therapy and HSCT. Nevertheless, AA is still one of the most challenging hematological disorders that could face a hematologist. This study was conducted at Assiut University Hospital (AUH), Assiut, Egypt to evaluate current situation and future prospective of AA. 63 patients with AA were prospectively enrolled in the study; they were admitted at the Hematology unit, AUH in the period 1stJan2011 to Feb2012, a 38 patients with iron deficiency anemia (IDA) were included for comparison. Patients' demographic and clinical data were collected through medical history and clinical examination. Both direct and indirect health care costs of anemia were assessed Direct parameters included doctors' and hospital fees, costs of laboratory investigations, medication fees and costs of HSCT or any procedure. Indirect costs included travelling expenses and earning losses. Social burden of anemia was estimated by anemia related morbidity and mortality. Data were analyzed with SPSSV.17, results showed that AA affected young age group with mean age 30.89±13.39 years, without sex predilection, acquired AA was more common than idiopathic (55.6% vs. 44.4%), however mortality was higher in idiopathic AA (46.2%). Causes of aplasia were exposure to chemicals, drugs and hepatitis in order. Only 63.5% of AA were admitted once and 47.6% in general ward, the mean hospital days for patients with AA was 17.73±11.10, compared to 8.32±6.69 in IDA, P=0.000, also higher socio-economic burden of AA was found compared with IDA. These results denoted that management of AA is still ineffective, and that there is a definite need for a strict plan to prevent incidence of AA, particularly in developing countries where effective management of AA is too expensive and relatively unavailable.},
 year = {2016}
}

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TY - JOUR
T1 - Aplastic Anemia in Egypt: Current Situation and Future Prospective
AU - Safaa A. A. Khaled
Y1 - 2016/05/11
PY - 2016
N1 - https://doi.org/10.11648/j.ajim.20160402.12
DO - 10.11648/j.ajim.20160402.12
T2 - American Journal of Internal Medicine
JF - American Journal of Internal Medicine
JO - American Journal of Internal Medicine
SP - 36
EP - 42
PB - Science Publishing Group
SN - 2330-4324
UR - https://doi.org/10.11648/j.ajim.20160402.12
AB - Aplastic anemia (AA) is a hypoproliferative anemia that led to a significant morbidity and mortality. Recently, dramatic improvement in prognosis of AA was achieved; this was in part due to advances in immunosuppressive therapy and HSCT. Nevertheless, AA is still one of the most challenging hematological disorders that could face a hematologist. This study was conducted at Assiut University Hospital (AUH), Assiut, Egypt to evaluate current situation and future prospective of AA. 63 patients with AA were prospectively enrolled in the study; they were admitted at the Hematology unit, AUH in the period 1stJan2011 to Feb2012, a 38 patients with iron deficiency anemia (IDA) were included for comparison. Patients' demographic and clinical data were collected through medical history and clinical examination. Both direct and indirect health care costs of anemia were assessed Direct parameters included doctors' and hospital fees, costs of laboratory investigations, medication fees and costs of HSCT or any procedure. Indirect costs included travelling expenses and earning losses. Social burden of anemia was estimated by anemia related morbidity and mortality. Data were analyzed with SPSSV.17, results showed that AA affected young age group with mean age 30.89±13.39 years, without sex predilection, acquired AA was more common than idiopathic (55.6% vs. 44.4%), however mortality was higher in idiopathic AA (46.2%). Causes of aplasia were exposure to chemicals, drugs and hepatitis in order. Only 63.5% of AA were admitted once and 47.6% in general ward, the mean hospital days for patients with AA was 17.73±11.10, compared to 8.32±6.69 in IDA, P=0.000, also higher socio-economic burden of AA was found compared with IDA. These results denoted that management of AA is still ineffective, and that there is a definite need for a strict plan to prevent incidence of AA, particularly in developing countries where effective management of AA is too expensive and relatively unavailable.
VL - 4
IS - 2
ER -

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Safaa A. A. Khaled

Department of Internal Medicine, Hematology & BMT Unit, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt

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APA Style

Safaa A. A. Khaled. (2016). Aplastic Anemia in Egypt: Current Situation and Future Prospective. American Journal of Internal Medicine, 4(2), 36-42. https://doi.org/10.11648/j.ajim.20160402.12

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ACS Style

Safaa A. A. Khaled. Aplastic Anemia in Egypt: Current Situation and Future Prospective. Am. J. Intern. Med. 2016, 4(2), 36-42. doi: 10.11648/j.ajim.20160402.12

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AMA Style

Safaa A. A. Khaled. Aplastic Anemia in Egypt: Current Situation and Future Prospective. Am J Intern Med. 2016;4(2):36-42. doi: 10.11648/j.ajim.20160402.12

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@article{10.11648/j.ajim.20160402.12,
  author = {Safaa A. A. Khaled},
  title = {Aplastic Anemia in Egypt: Current Situation and Future Prospective},
  journal = {American Journal of Internal Medicine},
  volume = {4},
  number = {2},
  pages = {36-42},
  doi = {10.11648/j.ajim.20160402.12},
  url = {https://doi.org/10.11648/j.ajim.20160402.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20160402.12},
  abstract = {Aplastic anemia (AA) is a hypoproliferative anemia that led to a significant morbidity and mortality. Recently, dramatic improvement in prognosis of AA was achieved; this was in part due to advances in immunosuppressive therapy and HSCT. Nevertheless, AA is still one of the most challenging hematological disorders that could face a hematologist. This study was conducted at Assiut University Hospital (AUH), Assiut, Egypt to evaluate current situation and future prospective of AA. 63 patients with AA were prospectively enrolled in the study; they were admitted at the Hematology unit, AUH in the period 1stJan2011 to Feb2012, a 38 patients with iron deficiency anemia (IDA) were included for comparison. Patients' demographic and clinical data were collected through medical history and clinical examination. Both direct and indirect health care costs of anemia were assessed Direct parameters included doctors' and hospital fees, costs of laboratory investigations, medication fees and costs of HSCT or any procedure. Indirect costs included travelling expenses and earning losses. Social burden of anemia was estimated by anemia related morbidity and mortality. Data were analyzed with SPSSV.17, results showed that AA affected young age group with mean age 30.89±13.39 years, without sex predilection, acquired AA was more common than idiopathic (55.6% vs. 44.4%), however mortality was higher in idiopathic AA (46.2%). Causes of aplasia were exposure to chemicals, drugs and hepatitis in order. Only 63.5% of AA were admitted once and 47.6% in general ward, the mean hospital days for patients with AA was 17.73±11.10, compared to 8.32±6.69 in IDA, P=0.000, also higher socio-economic burden of AA was found compared with IDA. These results denoted that management of AA is still ineffective, and that there is a definite need for a strict plan to prevent incidence of AA, particularly in developing countries where effective management of AA is too expensive and relatively unavailable.},
 year = {2016}
}

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