Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration

Komal Sharma

doi:doi:10.11648/j.js.20160402.20

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Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration

Komal Sharma

Published in Journal of Surgery (Volume 4, Issue 2)

Received: 22 May 2016 Published: 23 May 2016

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Abstract

Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and “in vivo” models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology; are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.

Published in	Journal of Surgery (Volume 4, Issue 2)
DOI	10.11648/j.js.20160402.20
Page(s)	49-59
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Biosynthetic Materials, Neural Growth, Neural Regeneration, Neurogenesis, Neurosurgery, Neurosurgical Research, Surgery, Surgical Research

References

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APA Style

Komal Sharma. (2016). Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. Journal of Surgery, 4(2), 49-59. https://doi.org/10.11648/j.js.20160402.20

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ACS Style

Komal Sharma. Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. J. Surg. 2016, 4(2), 49-59. doi: 10.11648/j.js.20160402.20

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AMA Style

Komal Sharma. Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. J Surg. 2016;4(2):49-59. doi: 10.11648/j.js.20160402.20

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@article{10.11648/j.js.20160402.20,
  author = {Komal Sharma},
  title = {Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration},
  journal = {Journal of Surgery},
  volume = {4},
  number = {2},
  pages = {49-59},
  doi = {10.11648/j.js.20160402.20},
  url = {https://doi.org/10.11648/j.js.20160402.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20160402.20},
  abstract = {Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and  “in vivo”  models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology;  are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.},
 year = {2016}
}

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TY  - JOUR
T1  - Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration
AU  - Komal Sharma
Y1  - 2016/05/23
PY  - 2016
N1  - https://doi.org/10.11648/j.js.20160402.20
DO  - 10.11648/j.js.20160402.20
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 49
EP  - 59
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20160402.20
AB  - Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and  “in vivo”  models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology;  are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.
VL  - 4
IS  - 2
ER  -

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Author Information

Komal Sharma

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

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APA Style

Komal Sharma. (2016). Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. Journal of Surgery, 4(2), 49-59. https://doi.org/10.11648/j.js.20160402.20

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ACS Style

Komal Sharma. Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. J. Surg. 2016, 4(2), 49-59. doi: 10.11648/j.js.20160402.20

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AMA Style

Komal Sharma. Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. J Surg. 2016;4(2):49-59. doi: 10.11648/j.js.20160402.20

Copy | Download

@article{10.11648/j.js.20160402.20,
  author = {Komal Sharma},
  title = {Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration},
  journal = {Journal of Surgery},
  volume = {4},
  number = {2},
  pages = {49-59},
  doi = {10.11648/j.js.20160402.20},
  url = {https://doi.org/10.11648/j.js.20160402.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20160402.20},
  abstract = {Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and  “in vivo”  models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology;  are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration
AU  - Komal Sharma
Y1  - 2016/05/23
PY  - 2016
N1  - https://doi.org/10.11648/j.js.20160402.20
DO  - 10.11648/j.js.20160402.20
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 49
EP  - 59
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20160402.20
AB  - Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and  “in vivo”  models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology;  are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.
VL  - 4
IS  - 2
ER  -

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