Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS and Klebsiella pneumoniae - induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD.
| Published in | Journal of Diseases and Medicinal Plants (Volume 3, Issue 1) |
| DOI | 10.11648/j.jdmp.20170301.14 |
| Page(s) | 17-22 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Eucalyptus Globulus, Lipopolysaccharide, Cytokine, Chronic Obstructive Pulmonary Disease
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APA Style
Lin Wang, Jianbo Sun, Wanzhong Li, Yanna Lv, Weiwei Shi, et al. (2017). Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats. Journal of Diseases and Medicinal Plants, 3(1), 17-22. https://doi.org/10.11648/j.jdmp.20170301.14
ACS Style
Lin Wang; Jianbo Sun; Wanzhong Li; Yanna Lv; Weiwei Shi, et al. Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats. J. Dis. Med. Plants 2017, 3(1), 17-22. doi: 10.11648/j.jdmp.20170301.14
AMA Style
Lin Wang, Jianbo Sun, Wanzhong Li, Yanna Lv, Weiwei Shi, et al. Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats. J Dis Med Plants. 2017;3(1):17-22. doi: 10.11648/j.jdmp.20170301.14
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Download@article{10.11648/j.jdmp.20170301.14,
author = {Lin Wang and Jianbo Sun and Wanzhong Li and Yanna Lv and Weiwei Shi and Chunzhen Zhao},
title = {Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats},
journal = {Journal of Diseases and Medicinal Plants},
volume = {3},
number = {1},
pages = {17-22},
doi = {10.11648/j.jdmp.20170301.14},
url = {https://doi.org/10.11648/j.jdmp.20170301.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20170301.14},
abstract = {Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS and Klebsiella pneumoniae - induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD.},
year = {2017}
}
TY - JOUR T1 - Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats AU - Lin Wang AU - Jianbo Sun AU - Wanzhong Li AU - Yanna Lv AU - Weiwei Shi AU - Chunzhen Zhao Y1 - 2017/03/01 PY - 2017 N1 - https://doi.org/10.11648/j.jdmp.20170301.14 DO - 10.11648/j.jdmp.20170301.14 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 17 EP - 22 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20170301.14 AB - Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS and Klebsiella pneumoniae - induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD. VL - 3 IS - 1 ER -
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