Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.
| Published in | Journal of Diseases and Medicinal Plants (Volume 3, Issue 1) |
| DOI | 10.11648/j.jdmp.20170301.12 |
| Page(s) | 7-11 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Aortic Tissue, Blood Pressure, Cardiovascular Diseases, Effect, Extract, Guinea Pigs, Hypertension, P. Guava
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APA Style
Abayneh Elias, Daniel Seifu, Frank Ashall, Tesfaye Tolessa. (2017). The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. Journal of Diseases and Medicinal Plants, 3(1), 7-11. https://doi.org/10.11648/j.jdmp.20170301.12
ACS Style
Abayneh Elias; Daniel Seifu; Frank Ashall; Tesfaye Tolessa. The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. J. Dis. Med. Plants 2017, 3(1), 7-11. doi: 10.11648/j.jdmp.20170301.12
AMA Style
Abayneh Elias, Daniel Seifu, Frank Ashall, Tesfaye Tolessa. The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. J Dis Med Plants. 2017;3(1):7-11. doi: 10.11648/j.jdmp.20170301.12
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Download@article{10.11648/j.jdmp.20170301.12,
author = {Abayneh Elias and Daniel Seifu and Frank Ashall and Tesfaye Tolessa},
title = {The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs},
journal = {Journal of Diseases and Medicinal Plants},
volume = {3},
number = {1},
pages = {7-11},
doi = {10.11648/j.jdmp.20170301.12},
url = {https://doi.org/10.11648/j.jdmp.20170301.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20170301.12},
abstract = {Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.},
year = {2017}
}
TY - JOUR T1 - The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs AU - Abayneh Elias AU - Daniel Seifu AU - Frank Ashall AU - Tesfaye Tolessa Y1 - 2017/02/16 PY - 2017 N1 - https://doi.org/10.11648/j.jdmp.20170301.12 DO - 10.11648/j.jdmp.20170301.12 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 7 EP - 11 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20170301.12 AB - Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals. VL - 3 IS - 1 ER -
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