Apoptosis in various cerebellar zones of juvenile masu salmon Oncorhynchus masou after mechanical injury was investigated by TUNEL-labeling. In the brain of 4 month-old juveniles of O. masou growth in different parts of cerebellum and proliferative activity in secondary matrix zones of cerebellum were continued. TUNEL-labeling was observed in the injured cerebellum 2 days after damage. The induction of proliferative activity in different matrix zones: granular eminences, dorsal part of molecular layer and surface layers of corpus cerebellum were noted. The proliferative activity in regional neurogenic niches is increased after injury of cerebellum. The maximal number of apoptotic elements in the cerebellum was observed in zones of the radial cell migration. We suggest that in damaged cerebellum both adult born cells and cells formed as a result of the reparative neurogenesis can be eliminated during radial migration as result of natural morphogenetic processes. Patterns of tangential and radial migration of cells were observed near the area of injury. The highest rate of apoptosis index was detected in the dorsal matrix zone corresponding to the zone of secondary neurogenesis. This testifies to the elimination of the newly formed cells at the stage of their localization in the matrix zones. The intensity of the apoptotic response varies in different areas of O. masou cerebellum.
| Published in |
American Journal of BioScience (Volume 3, Issue 2-3)
This article belongs to the Special Issue Adult and Reparative Neurogenesis: Actual Questions |
| DOI | 10.11648/j.ajbio.s.2015030203.13 |
| Page(s) | 19-27 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Apoptosis, Injury of Cerebellum, Dorsal Matrix Zone, Adult Neurogenesis, Oncorhynchus masou, Tangential and Radial Migration of Cells, Reparative Neurogenesis
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APA Style
Stukaneva M. E., Puschina E. V., Varaksin A. A., Shukla S. (2015). Monitoring of Cell Migration and Apoptosis in Cerebellum of Juvenile Masu Salmon Oncorhynchus Masou After Injury. American Journal of BioScience, 3(2-3), 19-27. https://doi.org/10.11648/j.ajbio.s.2015030203.13
ACS Style
Stukaneva M. E.; Puschina E. V.; Varaksin A. A.; Shukla S. Monitoring of Cell Migration and Apoptosis in Cerebellum of Juvenile Masu Salmon Oncorhynchus Masou After Injury. Am. J. BioScience 2015, 3(2-3), 19-27. doi: 10.11648/j.ajbio.s.2015030203.13
AMA Style
Stukaneva M. E., Puschina E. V., Varaksin A. A., Shukla S. Monitoring of Cell Migration and Apoptosis in Cerebellum of Juvenile Masu Salmon Oncorhynchus Masou After Injury. Am J BioScience. 2015;3(2-3):19-27. doi: 10.11648/j.ajbio.s.2015030203.13
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Download@article{10.11648/j.ajbio.s.2015030203.13,
author = {Stukaneva M. E. and Puschina E. V. and Varaksin A. A. and Shukla S.},
title = {Monitoring of Cell Migration and Apoptosis in Cerebellum of Juvenile Masu Salmon Oncorhynchus Masou After Injury},
journal = {American Journal of BioScience},
volume = {3},
number = {2-3},
pages = {19-27},
doi = {10.11648/j.ajbio.s.2015030203.13},
url = {https://doi.org/10.11648/j.ajbio.s.2015030203.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.s.2015030203.13},
abstract = {Apoptosis in various cerebellar zones of juvenile masu salmon Oncorhynchus masou after mechanical injury was investigated by TUNEL-labeling. In the brain of 4 month-old juveniles of O. masou growth in different parts of cerebellum and proliferative activity in secondary matrix zones of cerebellum were continued. TUNEL-labeling was observed in the injured cerebellum 2 days after damage. The induction of proliferative activity in different matrix zones: granular eminences, dorsal part of molecular layer and surface layers of corpus cerebellum were noted. The proliferative activity in regional neurogenic niches is increased after injury of cerebellum. The maximal number of apoptotic elements in the cerebellum was observed in zones of the radial cell migration. We suggest that in damaged cerebellum both adult born cells and cells formed as a result of the reparative neurogenesis can be eliminated during radial migration as result of natural morphogenetic processes. Patterns of tangential and radial migration of cells were observed near the area of injury. The highest rate of apoptosis index was detected in the dorsal matrix zone corresponding to the zone of secondary neurogenesis. This testifies to the elimination of the newly formed cells at the stage of their localization in the matrix zones. The intensity of the apoptotic response varies in different areas of O. masou cerebellum.},
year = {2015}
}
TY - JOUR T1 - Monitoring of Cell Migration and Apoptosis in Cerebellum of Juvenile Masu Salmon Oncorhynchus Masou After Injury AU - Stukaneva M. E. AU - Puschina E. V. AU - Varaksin A. A. AU - Shukla S. Y1 - 2015/03/05 PY - 2015 N1 - https://doi.org/10.11648/j.ajbio.s.2015030203.13 DO - 10.11648/j.ajbio.s.2015030203.13 T2 - American Journal of BioScience JF - American Journal of BioScience JO - American Journal of BioScience SP - 19 EP - 27 PB - Science Publishing Group SN - 2330-0167 UR - https://doi.org/10.11648/j.ajbio.s.2015030203.13 AB - Apoptosis in various cerebellar zones of juvenile masu salmon Oncorhynchus masou after mechanical injury was investigated by TUNEL-labeling. In the brain of 4 month-old juveniles of O. masou growth in different parts of cerebellum and proliferative activity in secondary matrix zones of cerebellum were continued. TUNEL-labeling was observed in the injured cerebellum 2 days after damage. The induction of proliferative activity in different matrix zones: granular eminences, dorsal part of molecular layer and surface layers of corpus cerebellum were noted. The proliferative activity in regional neurogenic niches is increased after injury of cerebellum. The maximal number of apoptotic elements in the cerebellum was observed in zones of the radial cell migration. We suggest that in damaged cerebellum both adult born cells and cells formed as a result of the reparative neurogenesis can be eliminated during radial migration as result of natural morphogenetic processes. Patterns of tangential and radial migration of cells were observed near the area of injury. The highest rate of apoptosis index was detected in the dorsal matrix zone corresponding to the zone of secondary neurogenesis. This testifies to the elimination of the newly formed cells at the stage of their localization in the matrix zones. The intensity of the apoptotic response varies in different areas of O. masou cerebellum. VL - 3 IS - 2-3 ER -
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